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> Home > Newsroom > Robin Warren
Lecture

Robin Warren Lecture

The Champalimaud Foundation welcomed the Nobel Laureate, Robin Warren, to
Lisbon on November 25th to speak about his award winning discovery of the
bacterium Helicobacter pylori.

Robin Warren and Barry Marshall were awarded the 2005 Nobel Prize in Medicine
and Physiology for their discovery of “the bacterium Helicobacter pylori and its
role in gastritis and peptic ulcer disease”

Drs. Warren and Marshall were recognised for their remarkable and unexpected
discovery that inflammation in the stomach (gastritis) as well as ulceration of
the stomach or duodenum (peptic ulcer disease) is the result of an infection of
the stomach caused by the bacterium Helicobacter pylori. Warren, a pathologist
from Perth, Australia, observed small curved bacteria colonising the lower part
of the stomach (antrum) in about 50% of patients from which biopsies had been
taken. He made the crucial observation that signs of inflammation were always
present in the gastric mucosa close to where the bacteria were seen. Marshall
became interested in Warren’s findings and together they initiated a study of
biopsies from 100 patients. After several attempts, Marshall succeeded in
cultivating a hitherto unknown bacterial species (later denoted Helicobacter
pylori) from several of these biopsies. Together they found that the organism
was present in almost all patients with gastric inflammation, duodenal ulcer or
gastric ulcer. Based on these results, they proposed that Helicobacter pylori is
involved in the aetiology of these diseases.In particular, infection with H.
pylori is the major risk factor for gastric cancer.

Even though peptic ulcers could be healed by inhibiting gastric acid
production, they frequently relapsed, since bacteria and chronic inflammation of
the stomach remained. In treatment studies, Marshall and Warren as well as
others showed that patients could be cured from their peptic ulcer disease only
when the bacteria were eradicated from the stomach. Thanks to the pioneering
discovery by Marshall and Warren, peptic ulcer disease is no longer a chronic,
frequently disabling condition, but a disease that can be cured by a short
regimen of antibiotics and acid secretion inhibitors.

In addition to his lecture at the Champalimaud Centre for the Unknown, Robin
Warren was in Lisbon to take part in the Science Matters conference.

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